Anti-brush border antibody disease
Definition
Anti-brush border antibody (ABBA) disease is a rare autoimmune kidney condition, specifically a form of tubulointerstitial nephritis, characterized by autoantibodies targeting the LRP2 (megalin) protein in the proximal tubules, leading to acute tubular injury and progressive renal failure.
Bilingual Equivalents
- Anti-brush border antibody disease
Grammatical & Source Details
Contextual Usage Examples
RO: Biopsia renală a confirmat diagnosticul de boală ABBA la un pacient vârstnic cu leziune renală acută.
EN: The kidney biopsy confirmed the diagnosis of ABBA disease in an elderly patient with acute kidney injury.
Idioms & Phrases
boala renală asociată cu ABBA / ABBA-associated renal disease
RO: Termen folosit pentru a descrie insuficiența renală cauzată direct de atacul anticorpilor asupra tubilor proximali.
EN: A term used to describe renal failure directly caused by the antibody attack on proximal tubules.
test serologic ABBA / ABBA serologic testing
RO: Analiză de laborator prin imunoflorescență utilizată pentru a detecta prezența autoanticorpilor în sânge.
EN: A laboratory immunofluorescence test used to detect the presence of autoantibodies in the blood.
depozite tubulare ABBA / ABBA tubular deposits
RO: Acumulări de complexe imune evidențiate la microscop de-a lungul membranei bazale tubulare.
EN: Immune complex accumulations highlighted under the microscope along the tubular basement membrane.